Les phospholipides phosphatidylglycérol (PG) portent une charge négative en raison de leurs groupes phosphate polaire chargés négativement, rendant la molécule entière chargée négativement. En fonction des chaînes d'acides gras, les phospholipides PG communs tels que le dipalmitoylphosphatidylglycérol (DPPG) et le dimyristoylphosphatidylglycérol (DMPG) présentent des différences significatives dans les températures de transition de phase.
N ° d'enregistrement de la CDE NMPA: F20180000838(A)
USFDA DMF no.: 032797
| Product Name | Dipalmitoyl Phosphatidylglycerole |
| Chemical Name | 1,2-Dipalmitoyl-sn-glycero-3-phosphatidylglycerol (sodium salt) |
| CAS No. | 200880-41-7 |
| NMPA CDE registration no. | F20180000838 |
| USFDA DMF No. | 032797 |
| Quality grade | Injection |
| Quality standards | Manufacturer's standard |
| Molecular Formula | C38H74O10PNa |
| Applications and examples | This product is Dipalmitoyl Phosphatidylglycerole (for injection), a fully synthetic phospholipid. It is suitable for the preparation of anionic liposomes and is a common choice of negatively charged membrane materials. It also plays a key role in improving the stability of liposomes. It has been widely used in the R&D of liposome drugs and the prescriptions of marketed products, and has also been used in some liposome projects in clinical stages, e.g., Lipoplatin. |
| Product code | S02003 |
| Package sizes | 1g, 10g |
| Storage condition | The product should be transported at -20 ± 5℃. It should be stored at -20℃ in well-closed containers, protected from light. Avoid exposure to strongly oxidizing media. It should be retested every 12 months when used and stored properly. |
Les phospholipides phosphatidylglycérol (PG) sont largement utilisés dans la préparation des liposomes;
Les particules lipidiques avec des charges négatives peuvent empêcher l'agrégation des particules, améliorant ainsi la stabilité des formulations;
Les particules lipidiques chargées négativement sont plus susceptibles de pénétrer dans les membranes cellulaires pour l'administration.
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